{"id":28005,"date":"2019-10-18T21:36:55","date_gmt":"2019-10-18T18:36:55","guid":{"rendered":"http:\/\/ihcoedu.uobaghdad.edu.iq\/?p=28005"},"modified":"2020-02-13T12:40:13","modified_gmt":"2020-02-13T09:40:13","slug":"%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%8a%d9%86%d8%a7%d9%82%d8%b4-%d8%b1%d8%b3%d8%a7%d9%84%d8%a9-%d9%85%d8%a7%d8%ac%d8%b3%d8%aa%d9%8a%d8%b1-%d8%aa%d8%a8-5","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=28005","title":{"rendered":"\u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u0628\u062d\u062b \u0641\u064a \u062a\u0623\u062b\u064a\u0631 \u062c\u0633\u064a\u0645\u0627\u062a \u0623\u0648\u0643\u0633\u064a\u062f \u0627\u0644\u0632\u0646\u0643 \u0627\u0644\u0646\u0627\u0646\u0648\u064a \u0641\u064a \u0643\u0644\u0649 \u0630\u0643\u0648\u0631 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0628\u064a\u0636"},"content":{"rendered":"

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\"\"<\/span><\/h4>\n

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\"\"<\/p>\n

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\u0627\u0633\u062a\u0646\u062a\u062c \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0645\u0627\u062f\u0629ZnO NPs \u00a0\u0628\u062a\u0631\u0643\u064a\u0632 150 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645 \u0648\u0644\u0644\u0645\u062f\u062a\u064a\u0646 \u0633\u0628\u0639\u0629 \u064814 \u064a\u0648\u0645\u0627\u064b \u0644\u0647 \u062a\u0623\u062b\u064a\u0631 \u0633\u0644\u0628\u064a \u0643\u0628\u064a\u0631 \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u0646\u0633\u062c\u064a \u0648\u0627\u0644\u0648\u0638\u064a\u0641\u064a \u0644\u0643\u0644\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0628\u064a\u0636.<\/span><\/h4>\n

\u0648\u062a\u0648\u0635\u0644 \u0627\u0644\u0637\u0627\u0644\u0628 \u0641\u064a \u062e\u062a\u0627\u0645 \u0628\u062d\u062b\u0647 \u0627\u0644\u0649 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629 :<\/span><\/h4>\n

\u064a\u062a\u0628\u064a\u0646 \u0645\u0645\u0627 \u0633\u0628\u0642 \u0627\u0646 \u062f\u0642\u0627\u0626\u0642 ZnO NPs \u0644\u0647\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0633\u0645\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0628\u064a\u0636 \u0644\u0627\u0633\u064a\u0645\u0627 \u0627\u0644\u0643\u0644\u0649 \u0644\u0630\u0627 \u062a\u0648\u0635\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0628\u0645\u0627 \u064a\u0623\u062a\u064a:-<\/span><\/h4>\n
    \n
  1. \n

    \u0627\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u062e\u0631\u0649 \u0644\u0645\u0639\u0631\u0641\u0629 \u062a\u0623\u062b\u064a\u0631 \u062f\u0642\u0627\u0626\u0642 ZnO NPs\u0641\u064a \u0627\u0639\u0636\u0627\u0621 \u0627\u062e\u0631\u0649 \u0645\u062b\u0644 \u0627\u0644\u062f\u0645\u0627\u063a \u0648\u0627\u0644\u0642\u0644\u0628.<\/span><\/h4>\n<\/li>\n
  2. \n

    \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062f\u0642\u0627\u0626\u0642 \u0646\u0627\u0646\u0648\u064a\u0629 \u0630\u0627\u062a \u062d\u062c\u0645 \u0627\u0642\u0644 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u0639\u0645\u0644\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0648\u0645\u0639\u0631\u0641\u0629 \u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647\u0627 \u0641\u064a \u0627\u0639\u0636\u0627\u0621 \u0627\u0644\u062c\u0633\u0645.<\/span><\/h4>\n<\/li>\n
  3. \n

    \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0646\u0627\u0641\u0630 \u0644\u0645\u0639\u0631\u0641\u0629 \u062a\u0631\u0633\u0628\u0627\u062a \u0627\u0644\u062f\u0642\u0627\u0626\u0642 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0641\u064a \u0639\u0636\u064a\u0627\u062a \u0646\u0633\u062c \u0627\u0644\u0627\u0639\u0636\u0627\u0621 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629.<\/span><\/h4>\n<\/li>\n
  4. \n

    \u0627\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0628\u0627\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u062a\u0623\u062b\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u062f\u0642\u0627\u0626\u0642.\u00a0 \u00a0<\/span><\/h4>\n
    \n

    \u00a0<\/span><\/h3>\n

    The impact of Zinc oxide nanoparticles(ZnO NPs) on the morphological, weight, biometric, functional and histopathological changes in the kidney of male albino mice Mus musculu<\/span><\/h3>\n

    <\/h3>\n

    By Basim Sultan Obaid<\/span><\/h3>\n

    Supervised by Asst. prof. Dr.Genan Al-Bairuty<\/span><\/h3>\n

    Abstract<\/span><\/h3>\n

    The current study was conducted to investigate the impact of Zinc oxide nanoparticles(ZnO NPs) on the morphological, weight, biometric, functional and histopathological changes in the kidney of male albino mice (Mus musculus).The research included the following set of criteria:<\/span><\/h3>\n

    1- Studying the morphological description of animals and kidneys.<\/span><\/h3>\n

    2-Measurement \u00a0\u00a0of animal body weights before and after the injections as well as weights and dimensions of kidneys.<\/span><\/h3>\n

    3-Functional \u00a0parameters measurements (Creatinine, urea, and uric acid)<\/span><\/h3>\n

    4-Measurement of bio metric changes and histopathological alterations in kidney tissues<\/span><\/h3>\n

    In the experiment, 24 male albino mice were divided into four groups, using six animals in each group. The first and second groups were injected into the peritoneum (IP) with 0.1 ml of 150 mg\/kg of ZnO NPs (25-45 nm) for 7 and 14 days respectively. The third and fourth groups \u00a0are the control groups that were injected with 0.1 ml of 0.9 percent of sodium chloride solution into peritoneum for seven and 14 days respectively.<\/span><\/h3>\n

    Blood was withdrawn from the injected groups for the purpose of measuring functional changes in the kidneys, namely creatinine, urea, and uric acid, as well as collecting the right kidney samples for the purpose of histological studies after the animals were sacrificed.<\/span><\/h3>\n

    The morphological results showed a decrease in the appearance of fatty substance surrounding the kidney and the accumulation of ZnO NPs on the outer part of the kidneys with a pale kidney color. The results also showed a significant reduction\u00a0 P \u2264 0.05 ) in the weight of animals that were injected for 14 days compared with the control group of the same duration<\/span><\/h3>\n

    The functional study of kidney results illustrated a significant increase ( P \u2264 0.05 ) in the average level of serum creatinine and urea concentration in animals that were injected with 150 mg \/ kg of ZnO NPs for two periods(7 and 14 days) compared with the control group for the same duration ,while no significant differences (P> 0.05) in the average level of serum uric acid in animals that were injected with 150 mg \/ kg of ZnO NPs for 7 and 14 days compared to the control groups of the same duration.<\/span><\/h3>\n

    The results of the biometric study showed a significant increase ( P \u2264 0.05 ) in the average diameters of proximal and distal renal tubules in animals that were injected with ZnO NPs for seven and 14 days compared to the control groups of the same duration of exposure. The results showed a significant increase ( P \u2264 0.05 ) in the rate of expansion of Baumann’s capsule space in animals that were injected with ZnO NPs for a period of 7 days. The rate of expansion was increased by increasing the duration of injection (14-day) compared with the control groups of the same duration of exposure. The results also showed a significant decrease ( P \u2264 0.05 ) in the average diameter of glomeruli in animals that were injected with ZnO NPS for a period of 14 days compared with the control groups that have been injected with the sodium chloride for the same period<\/span><\/h3>\n

    The results showed significant incidence of histopathological changes in the structure of animal kidneys that have been injected with ZnO NPsfor a period of 7 days, including a blood congestion in most of the kidney tissues, especially in the blood vessels and between renal tubules, accumulation of inflammatory cells between renal corpuscle and renal tubules, necrosis in the lining of epithelial cells in the tubules, loss of some renal glomeruli, sloughing of epithelial cells from the basement membrane, expansion of Bowmann’s capsule space, and the hypertrophy of some nucleus in lining epithelial cells of renal tubules .The severity changes were increased in animals that have been injected for 14 days as it showed other changes such as shrinkage and degeneration of renal glomeruli, and calcium molds are formed within the tubules<\/span><\/h3>\n

    From this study ,we conclude that exposure to ZnO NPS for 7 and 14 days at a concentration of 150 mg\/kg has a major adverse impact on the tissue structure and function of kidney in albino mice<\/span><\/h3>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/span><\/h4>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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