{"id":28252,"date":"2019-11-14T11:52:53","date_gmt":"2019-11-14T08:52:53","guid":{"rendered":"http:\/\/ihcoedu.uobaghdad.edu.iq\/?p=28252"},"modified":"2019-11-17T11:44:47","modified_gmt":"2019-11-17T08:44:47","slug":"%d9%82%d8%b3%d9%85-%d8%a7%d9%84%d9%83%d9%8a%d9%85%d9%8a%d8%a7%d8%a1-%d9%8a%d9%86%d8%a7%d9%82%d8%b4-%d8%b1%d8%b3%d8%a7%d9%84%d8%a9-%d9%85%d8%a7%d8%ac%d8%b3%d8%aa%d9%8a%d8%b1-%d8%aa%d8%a8%d8%ad%d8%ab-6","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=28252","title":{"rendered":"\u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u0628\u062d\u062b \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0628\u0627\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0644\u062d\u0648\u0627\u0645\u0636 \u0627\u0644\u0627\u0645\u0643 \u0648\u0645\u0634\u062a\u0642\u0627\u062a\u0647\u0627 \u0645\u0646 \u062d\u0627\u0645\u0636 \u0627\u0644\u0645\u064a\u0641\u064a\u0646\u0627\u0645\u064a\u0643"},"content":{"rendered":"

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\u062e\u0627\u0645\u0633\u0627: \u0623\u0646 \u0627\u0644\u0645\u0634\u062a\u0642\u0627\u062a \u00a0\u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u00a0\u062a\u062d\u062a\u0648\u064a \u062a\u062d\u062a\u0648\u064a \u00a0\u062d\u0644\u0642\u0627\u062a \u0631\u0628\u0627\u0639\u064a\u0629 \u00a0\u0648\u062e\u0645\u0627\u0633\u064a\u0629 \u00a0\u0643\u0623\u0627\u0632\u064a\u062a\u064a\u062f\u064a\u0646\u00a0 [VIII]a-c \u0648 \u0623\u064a\u0645\u064a\u062f\u0627\u0644\u0632\u0648\u0644\u064a\u062f\u064a\u0646 \u00a0\u0648\u062b\u0627\u064a\u0648\u0632\u0648\u0644\u064a\u062f\u064a\u0646 [IX]a-c\u00a0\u00a0 \u00a0\u00a0\u0648\u0642\u062f \u0623\u062f\u0649 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0642\u0627\u0639\u062f\u0629 \u0634\u064a\u0641 [VII]a \u00a0\u0645\u0639 \u0627\u0644\u0643\u0644\u0648\u0631\u0648\u0627\u0633\u064a\u062a\u064a\u0644 \u0643\u0644\u0648\u0631\u0627\u064a\u062f \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u062a\u0631\u0627\u064a \u0627\u062b\u064a\u0644 \u0627\u0645\u064a\u0646 \u0627\u0644\u0649 \u062a\u0643\u0648\u064a\u0646 \u0623\u0632\u064a\u062a\u064a\u062f\u064a\u0646 \u062c\u062f\u064a\u062f [VIII]a-c \u00a0\u0648\u0628\u064a\u0646\u0645\u0627 \u062a\u0645 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0623\u064a\u0645\u064a\u062f\u0627\u0632\u0648\u0644\u064a\u062f\u064a\u0646[X]a-c \u0648\u062b\u0627\u064a\u0627\u0632\u0648\u0644\u064a\u062f\u064a\u0646 [XI]a–c \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u0635\u0639\u064a\u062f \u0642\u0627\u0639\u062f\u0629 \u0634\u0641 \u0627\u0644\u0645\u0630\u0643\u0648\u0631\u0629 [VII]a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0643\u0644\u0627\u064a\u0633\u064a\u0646 \u0641\u064a \u0627\u0644\u062a\u0631\u0627\u064a \u0627\u062b\u064a\u0644 \u0627\u0645\u064a\u0646 \u0648\u062d\u0627\u0645\u0636 \u0627\u0644\u062b\u0627\u064a\u0648\u0643\u0644\u0648\u0643\u0648\u0644\u064a\u0643 \u0641\u064a \u0627\u0644\u0628\u0646\u0632\u064a\u0646 \u0627\u0644\u062c\u0627\u0641 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/span><\/h4>\n

\u0634\u062e\u0635\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 FTIR \u060c 1HNMR \u060c\u0637\u064a\u0641 \u0627\u0644\u0643\u062a\u0644\u0629 \u0648.CHN \u00a0<\/span><\/h4>\n

\u0633\u0627\u062f\u0633\u0627:\u00a0\u00a0 \u062a\u0645 \u0641\u062d\u0635 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0644\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u0644\u0645\u0639\u0638\u0645\u0647\u0627 \u0646\u0634\u0627\u0637 \u062c\u064a\u062f \u0645\u0636\u0627\u062f \u0644\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627. \u0623\u064a\u0636\u0627 \u060c \u062a\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0633\u0627\u0645 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u062e\u0644\u0642\u0629 \u0639\u0644\u0649 \u062e\u0637 \u062e\u0644\u0627\u064a\u0627 MCF-7 (\u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0628\u0634\u0631\u064a\u0629) \u0648\u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0644\u0628\u0639\u0636\u0647\u0627 \u060c \u0645\u0645\u0627 \u0634\u062c\u0639\u0646\u0627 \u0639\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0633\u0645\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0643\u0627\u0626\u0646\u0627\u062a \u0627\u0644\u062d\u064a\u0629 (\u0627\u0644\u0641\u0626\u0631\u0627\u0646) \u0644\u062a\u0642\u064a\u064a\u0645 \u0633\u0645\u064a\u062a\u0647 \u0627\u0644\u062d\u0627\u062f\u0629 \u0648\u062b\u0628\u062a \u0646\u062a\u0627\u0626\u062c \u0639\u062f\u0645 \u0633\u0645\u064a\u0629 \u0627\u0644\u0645\u0634\u062a\u0642\u0627\u062a.<\/span><\/h4>\n
\n

Synthesis and biological activities of some new amic acid and their derivatives of Mefenamic acid<\/strong><\/span><\/h3>\n

By Ali Emad Sabah<\/span><\/h3>\n

Supervised by \u00a0Assist .prof.Dr.Muna Sameer Al-Rawi<\/span><\/h3>\n

Abstract<\/strong><\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Amic acid represent a major class of organic compounds and some of As\u00a0 derivatives were used \u00a0in\u00a0 drug industry , Therefore modification structure of the amic acid derived from mefenamic acid have allowed using multistep processes to the synthesize of new derivatives that may be having a broad spectrum of biological activity and fewer side effects than the original compound.<\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 For this purpose in this work, mefenamic acid was used as a starting material for the preparation of amic acid and us derivatives via multistep synthesis as fallowing<\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 First: compound [I] which was prepared by the reaction between the carboxylic acid group in mefenamic acid and methanol in acidic medium, which was converted to acorresebonding acid hydrazide [II]<\/span><\/h3>\n

\u00a0\u00a0 Second: the key intermediate amic acids [III]a-e<\/sub> were synthesized by refluxing of acid hydrazid of mefenamic acid[II] with different anhydrides\u00a0 (maleic, succinic, phthalic, 3-nitrophthalic, or naphthalic anhydride) in dry benzene<\/span><\/h3>\n

\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Third: dehydration of the synthesized amic acid [III]a-e<\/sub> by acetic anhydride and anhydrous sodium acetate producing the new type of imide compound [IV]a-e<\/sub>\u00a0<\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fourth: the esterification of hydroxyl groups of amic acid [III]a<\/sub>to produce corresponding new ester[V], which was condensed with hydrazine hydrate to give acid hydrazide [VI], then the later compound reacted with substituted aromatic aldehydes (syringaldehyde, 4-nitrobenzaldehyde or vaniline) in dry benzene using glacial acetic acid as a catalyst under reflux producing the target Schiff bases[VII]a-c<\/sub><\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fifth: the new derivatives containing heterocyclic unit four and five\u00a0 member ring were formed such as azetidin-2-one [VIII]a-c<\/sub>, imidazolidin-4-one [X]a-c<\/sub>, andthiazolidin-4-one [IX]a-c<\/sub>.\u00a0 The reaction of Schiff base [VII]a<\/sub> with chloroacetylchloride in the presence of triethylamine led to the formation of\u00a0 the new target azetidin-2-one [VIII]a-c <\/sub>. While the imidazolidin-4-one [X]a-c<\/sub> and thiazolidin-4-one [XI]a-c<\/sub> derivatives were produced by heating the mentioned schiff bases [VII]a-c<\/sub> with glycine in triethylamine , and thioglycolic acid in dry benzene, respectively<\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The structures of the synthesized compounds were confirmed using FTIR, 1<\/sup>HNMR, mass and CHN-S (some of them) techniques<\/span><\/h3>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sixth: antimicrobial activity for some of the synthesized compounds were examined against different types of bacteria and the results showed that most of them have a good anti bacterial activity. Also,the cytotoxic effect of some the synthesized compounds was tested against MCF-7 cell line (human breast carcinoma cells)and positive results were obtained for some of them, which encouraged us to study the toxicity using living organisms (mice) to evaluate its acute toxicity and proved the results of non-toxicity of the derivatives<\/span><\/h3>\n

<\/h3>\n","protected":false},"excerpt":{"rendered":"

\u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 (\u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645) \u0631\u0633\u0627\u0644\u0629 \u0627\u0644\u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 ( \u062a\u062d\u0636\u064a\u0631 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u0628\u0627\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0644\u0628\u0639\u0636 \u062d\u0648\u0627\u0645\u0636 \u0627\u0644\u0627\u0645\u0643….<\/i>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":25,"featured_media":28253,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[7,16],"tags":[23],"class_list":["post-28252","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7","category-16","tag-ihcoedu"],"modified_by":"ihcoedu","_links":{"self":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/28252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28252"}],"version-history":[{"count":0,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/28252\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/28253"}],"wp:attachment":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}