{"id":29890,"date":"2020-01-30T11:00:01","date_gmt":"2020-01-30T08:00:01","guid":{"rendered":"http:\/\/ihcoedu.uobaghdad.edu.iq\/?p=29890"},"modified":"2020-02-02T12:44:02","modified_gmt":"2020-02-02T09:44:02","slug":"%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%8a%d9%86%d8%a7%d9%82%d8%b4-%d8%b1%d8%b3%d8%a7%d9%84%d8%a9-%d9%85%d8%a7%d8%ac%d8%b3%d8%aa%d9%8a%d8%b1-%d8%aa-11","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=29890","title":{"rendered":"\u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u0628\u062d\u062b \u062f\u0648\u0631 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0641\u064a \u0637\u0631\u064a\u0642\u0629 \u062a\u0637\u0648\u0631 \u0645\u0631\u0636 \u0627\u0644\u062a\u062d\u0633\u0633 \u0627\u0644\u0642\u0645\u062d"},"content":{"rendered":"

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\"\"<\/p>\n

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    \n
  1. \n

    \u062a\u0642\u064a\u064a\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0646\u062a\u0631\u0644\u064a\u0648\u0643\u064a\u0646-1\u0628\u064a\u062a\u0627 (IL-1\u03b2) \u0641\u064a \u0645\u0635\u0648\u0644 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629 \u0648\u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629.<\/span><\/h4>\n<\/li>\n
  2. \n

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  3. \n

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    \"\"<\/p>\n

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      \n
    1. \n

      \u0623\u0632\u062f\u0627\u062f \u062d\u062f\u0648\u062b \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0627\u0644\u0627\u0637\u0641\u0627\u0644 \u0628\u0639\u0645\u0631 (5-9) \u0648\u0627\u0644\u0639\u0645\u0631 (10-14) \u0628\u0646\u0633\u0628\u0629 40% \u064850% \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0648\u0628\u0644\u063a \u0645\u0639\u062f\u0644 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI) \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (2.4\u00b12.51\u0643\u063a\u0645\/\u06452<\/sup>) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (18.2\u00b13.6 \u0643\u063a\u0645\/\u06452<\/sup>( \u0645\u0639 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u2264 0.05). \u0648\u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0648\u0632\u0646\u060c \u0641\u0642\u062f \u0627\u0638\u0647\u0631 \u0645\u062a\u0648\u0633\u0637 \u0648\u0632\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0646\u062e\u0641\u0627\u0638\u0627 \u0645\u0639\u0646\u0648\u064a\u0627 \u0648\u0627\u0636\u062d\u0627 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (22.9\u00b17.2 \u064831.1\u00b111.6 \u0643\u063a\u0645 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a) (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629\u2264 0.05). \u0648\u0642\u062f \u0643\u0627\u0646 \u062a\u0643\u0631\u0627\u0631 \u062d\u0635\u0648\u0644 \u0627\u0644\u0645\u0631\u0636 \u062d\u0648\u0627\u0644\u064a (73.3%) \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0627\u0628\u0627\u0621 \u0627\u0644\u0627\u0642\u0627\u0631\u0628 \u064a\u062a\u0628\u0639\u0647 (26.7%) \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0627\u0628\u0648\u064a\u0646 \u063a\u064a\u0631 \u0627\u0642\u0631\u0628\u0627\u0621 \u0648\u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629> 0.05). \u0648\u0643\u0627\u0646 \u062a\u0643\u0631\u0627\u0631 \u062d\u062f\u0648\u062b \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0627\u0644\u0627\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0645\u0631\u0636 \u0627\u0639\u0644\u0649 \u0628\u0643\u062b\u064a\u0631 (66.7%) \u0645\u0646 \u0627\u0644\u0627\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u0643\u0627\u0646\u062a \u0639\u0648\u0627\u0626\u0644\u0647\u0645 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 (%33.3) (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u2264 0.05). \u0648\u0643\u0630\u0644\u0643 \u0627\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0632\u064a\u0627\u062f\u0629 \u0627\u0635\u0627\u0628\u0629 \u0627\u0644\u0627\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u062a\u0639\u0627\u0646\u064a \u0639\u0648\u0627\u0626\u0644\u0647\u0645 \u0645\u0646 \u0627\u0644\u0627\u0645\u0631\u0627\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0648\u062e\u0627\u0635\u0629 \u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631 \u0628\u0646\u0633\u0628\u0629 (53.3%) \u0648\u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0633\u0645\u0627\u0645 \u0627\u0644\u062f\u0631\u0642\u064a\u00a0 \u0628\u0646\u0633\u0628\u0629 (%6.7) (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629\u2264 0.05)\u060c \u0645\u0645\u0627 \u064a\u0643\u0634\u0641 \u0639\u0646 \u0648\u062c\u0648\u062f \u0635\u0644\u0647 \u062c\u064a\u0646\u064a\u0647 \u0642\u0648\u064a\u0647 \u0628\u064a\u0646 \u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0645\u0639 \u0645\u0631\u0636 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0642\u0645\u062d.<\/span><\/h4>\n<\/li>\n
    2. \n

      \u0648\u0628\u0627\u0644\u0627\u0633\u062a\u0646\u0627\u062f \u0627\u0644\u0649 \u062a\u0635\u0646\u064a\u0641 \u0645\u0627\u0631\u0634\u060c \u0641\u0642\u062f \u0643\u0634\u0641\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0646 \u0632\u064a\u0627\u062f\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0627\u0639\u062f\u0627\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0636\u0645\u0648\u0631 \u062c\u0632\u0626\u064a \u0628\u0632\u063a\u0627\u0628\u0627\u062a \u0627\u0644\u0627\u0645\u0639\u0627\u0621 \u0645\u0646 \u0627\u0644\u0635\u0646\u0641 Marsh \u0428 A)) \u0648\u0628\u0646\u0633\u0628\u0629(70%) \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0636\u0645\u0648\u0631 \u0627\u0644\u0627\u0642\u0644 \u0645\u0646 \u0627\u0644\u0643\u0644\u064a Marsh III B\u0648\u0627\u0644\u0636\u0645\u0648\u0631 \u0627\u0644\u0643\u0644\u064aMarsh IIIC \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0627\u0642\u0644 \u0648\u0628\u0646\u0633\u0628\u0629 13.3%, 16.7%)\u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a)\u060c \u0641\u064a \u062d\u064a\u0646 \u0644\u0645 \u062a\u0638\u0647\u0631 \u062d\u0627\u0644\u0627\u062a Marsh I \u0648\u0644\u0627 Marsh II \u0628\u064a\u0646 \u0645\u062c\u0627\u0645\u064a\u0639 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/span><\/h4>\n<\/li>\n
    3. \n

      \u0627\u0638\u0647\u0631 \u0645\u0631\u0636\u0649 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0642\u0645\u062d \u0627\u0631\u062a\u0641\u0627\u0639\u0627 \u0645\u0639\u0646\u0648\u064a\u0627 \u0643\u0628\u064a\u0631\u0627 \u0641\u064a \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0627\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 IgA \u0644\u0644\u062c\u0644\u064a\u0627\u062f\u064a\u0646 (119.4\u00b1 83.8 \u0648\u062d\u062f\u0629\/\u0645\u0644) (\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629\u22640.05) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0647 \u0627\u0644\u062a\u062d\u0643\u0645 (0.4\u00b10.8 \u0648\u062d\u062f\u0629\/\u0645\u0644)\u060c \u0641\u064a \u062d\u064a\u0646 \u0627\u0638\u0647\u0631\u062a \u0627\u0644\u0627\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0648\u062c\u0647\u0629 \u0636\u062f tTG \u0627\u0647\u0645\u064a\u0629 \u0627\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0627\u0644\u064a\u0647 \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (349.3\u00b1556.1 \u06480.9\u00b10.5 \u0648\u062d\u062f\u0629\/\u0645\u0644 \u0639\u0644\u064a \u0627\u0644\u062a\u0648\u0627\u0644\u064a)\u060c \u0644\u0645 \u062a\u0648\u062c\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 (\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629> 0.05) \u0644\u0644\u0627\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u062c\u0644\u064a\u0627\u062f\u064a\u0646 \u0648\u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0648\u062c\u0647\u0629 \u0636\u062f tTG \u0645\u0639 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0642\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0627\u0644\u0639\u0645\u0631\u060c \u0627\u0644\u062c\u0646\u0633\u060c \u0645\u0624\u0634\u0631 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI)\u060c \u062f\u0631\u062c\u0629 \u0627\u0644\u0642\u0631\u0627\u0628\u0629 \u0628\u064a\u0646 \u0627\u0644\u0627\u0628\u0648\u064a\u0646\u060c \u062a\u0623\u0631\u064a\u062e \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0627\u0644\u0639\u0627\u0626\u0644\u0629\u060c \u0627\u0644\u0627\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0641\u064a \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0627\u0636\u0627\u0641\u0629 \u0627\u0644\u0649 \u062a\u0635\u0646\u064a\u0641 \u0645\u0627\u0631\u0634.<\/span><\/h4>\n<\/li>\n
    4. \n

      \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0627\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0648\u062c\u0647\u0629 \u0636\u062f tTG \u0641\u0631\u0648\u0642\u0627 \u0645\u0639\u0646\u0648\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 (\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629\u2264 0.05) \u0645\u0639 \u0627\u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u062f\u0631\u064a\u062c\u064a\u0647 \u0641\u064a \u0645\u0633\u062a\u0648\u064a \u062a\u0644\u0641 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u0645\u0635\u0646\u0641\u0629 \u0645\u0646 \u0642\u0628\u0644Marsh Marsh IIIA) 202.5\u00b1345.6 \u0648\u062d\u062f\u0629\/\u0645\u0644\u060cIIIB \u00a0382.5 \u00b1 255.5 Marsh \u0648\u062d\u062f\u0629\/\u0645\u0644 \u0648IIIC \u00a0Marsh939.4\u00b11022.8 \u0648\u062d\u062f\u0629\/\u0645\u0644 \u0648\u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a).<\/span><\/h4>\n<\/li>\n
    5. \n

      \u0627\u0631\u062a\u0641\u0639 \u0645\u062a\u0648\u0633\u0640\u0640\u0640\u0640\u0640\u0637 \u062a\u0631\u0643\u0640\u0640\u0640\u0640\u0640\u0640\u064a\u0632 \u0627\u0644\u0627\u0646\u062a\u0631\u0644\u0640\u0640\u0640\u0640\u0640\u0640\u0640\u0648\u0643\u064a\u0646 1-\u0628\u064a\u062a\u0627 (IL-1\u03b2) \u0641\u064a \u0645\u0635\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0631\u062a\u0641\u0627\u0639\u0627\u064b \u0637\u0641\u064a\u0641\u0627\u064b (82.7 \u00b1179.4 \u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645 \/\u0645\u0644) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (51.5 \u00b171.6\u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645 \/\u0645\u0644) \u0645\u0639 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 (\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629> 0.05). \u0648\u0643\u0630\u0644\u0643 \u0627\u0648\u0636\u062d\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0646 \u0647\u0646\u0627\u0643 \u0632\u064a\u0627\u062f\u0629 \u0637\u0641\u064a\u0641\u0647 \u0641\u064a \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628inflammasome NLRP3 \u0641\u064a \u0645\u0631\u0636\u0649 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u062d\u0646\u0637\u0629 (10.5\u00b13.4) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0647 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (1.8\u00b11.7)\u060c \u0648\u0644\u0645 \u062a\u0638\u0647\u0631 \u0641\u0631\u0648\u0642 \u0627\u062d\u0635\u0627\u0626\u064a\u0647 \u0643\u0628\u064a\u0631\u0629 (\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629>0.05) \u0645\u0627 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a IL-1\u03b2 \u0648\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 inflammasome \u00a0NLRP3\u0645\u0639 \u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (\u0627\u0644\u0645\u0630\u0643\u0648\u0631\u0629 \u0633\u0627\u0628\u0642\u0627\u064b) \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/span><\/h4>\n<\/li>\n
    6. \n

      \u0623\u0638\u0647\u0631 \u062a\u062d\u0644\u064a\u0644 ROC \u062d\u0633\u0627\u0633\u064a\u0629 \u0648\u062e\u0635\u0648\u0635\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 \u0644\u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u062c\u0644\u064a\u0627\u062f\u064a\u0646IgA anti-gliadin \u0648\u0644\u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0646\u0632\u064a\u0645 \u0627\u0644\u0643\u0644\u0648\u062a\u0627\u0645\u064a\u0646\u064a\u0632 \u0641\u064a \u0627\u0644\u0646\u0633\u064a\u062c anti-tTG\u0641\u064a \u0645\u0635\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 (100\u066a\u060c 95 \u064891.7\u066a\u060c 90 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a)\u060c \u0627\u0630 \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u062a\u062d\u062a \u0627\u0644\u0645\u0646\u062d\u0646\u0649 (AUC) \u0644\u0644\u0640 anti-gliadin \u0623\u0639\u0644\u0649 \u0648\u0628\u0634\u0643\u0644 \u0645\u0639\u0646\u0648\u064a 0.99)) \u0645\u0646 (AUC) \u0644\u0644\u0640 anti-tTG \u00a0((0.95. \u0648\u0642\u062f \u0623\u0638\u0647\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a(\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629<0.05 (\u0627\u0646 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645 \u062a\u0643\u0646 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629. \u00a0<\/span><\/h4>\n<\/li>\n<\/ol>\n

      <\/h4>\n

      <\/h4>\n

      \u0648\u0641\u064a \u062e\u062a\u0627\u0645 \u0627\u0644\u0628\u062d\u062b \u062e\u0644\u0635\u062a \u0627\u0644\u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u0649 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u0627\u062a\u064a\u0629 :<\/span><\/h4>\n
        \n
      1. \n

        \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u062f\u0648\u0631 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u0644\u062a\u0647\u0627\u0628 NLRP3 Inflammasome \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064a \u0623\u0636\u0627\u0641\u0629 \u0644\u0644\u0623\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629 \u0648\u0630\u0644\u0643 \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629 \u0641\u0642\u0637.<\/span><\/h4>\n<\/li>\n
      2. \n

        \u0625\u062c\u0631\u0627\u0621 \u00a0\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0639\u0632\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629 \u00a0\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u062a \u0627\u0644\u0623\u0644\u062a\u0647\u0627\u0628 NLRP3 Inflammasome \u00a0.<\/span><\/h4>\n<\/li>\n
      3. \n

        \u064a\u0648\u0635\u0649 \u0628\u062f\u0631\u0627\u0633\u0629 \u0623\u0646\u0648\u0627\u0639 \u0623\u062e\u0631\u0649 \u0645\u0646 \u062c\u0632\u064a\u0626\u0627\u062a NLRP \u0645\u062b\u0644 NLRP1 \u060c ) NLRP4\u0648\u0630\u0644\u0643 \u0644\u0623\u0646\u0647\u0627 \u062a\u0634\u0643\u0644 \u0623\u064a\u0636\u064b\u0627 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u060c \u0648\u0644\u0627 \u0632\u0627\u0644\u062a \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0639\u0646\u0647\u0627 \u0645\u062d\u062f\u0648\u062f\u0629) \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u062f\u0648\u0631 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0645 \u0648\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u062a\u0637\u0648\u0631 \u0645\u0631\u0636 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629.<\/span><\/h4>\n<\/li>\n
      4. \n

        \u00a0\u062a\u0642\u064a\u064a\u0645 \u0645\u0633\u062a\u0648\u0649 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a NLRP3 Inflammasome\u0628\u0648\u0627\u0633\u0637\u0629 \u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0623\u0645\u062a\u0632\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a (ELISA) \u00a0\u0644\u0623\u064a\u062c\u0627\u062f \u0645\u0633\u062a\u0648\u0649 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u064a \u0645\u0635\u0644 \u0648\u0628\u064a\u0646 \u062a\u0639\u0628\u064a\u0631\u0647 \u0627\u0644\u062c\u064a\u0646\u064a \u0641\u064a \u0645\u0631\u0636\u0649 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0647\u0636\u0645\u064a\u0629.<\/span><\/h4>\n<\/li>\n
      5. \n

        \u00a0\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0640 IL-1\u03b2 \u0648\u0645\u0642\u0627\u0631\u0646\u062a\u0647 \u0628\u0645\u0633\u062a\u0648\u0649 \u0641\u064a \u0627\u0644\u0645\u0635\u0644. \u00a0\u0648\u0645\u0646 \u0627\u0644\u0645\u062b\u064a\u0631 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u062f\u0631\u0627\u0633\u0629 \u062f\u0648\u0631\u00a0 \u00a0\u00a0IL-18 \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 IL-1beta \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0644\u0643\u0648\u0646\u0647 \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u064b\u0627 \u0641\u064a \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629.<\/span><\/h4>\n<\/li>\n
      6. \n

        \u00a0\u0646\u0648\u0635\u064a \u0628\u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 NLRP3 \u0643\u0639\u0627\u0645\u0644 \u062d\u064a\u0648\u064a \u0643\u0627\u0634\u0641 \u0639\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0645\u0631\u0636 \u0648\u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u0647\u062f\u0627\u0641\u0647 \u0643\u0639\u0644\u0627\u062c.<\/span><\/h4>\n
        \n

        The Role of Inflammasome in Pathogenesis of Celiac Disease<\/span><\/h3>\n

        By Hiba Mouhsen Ali<\/span><\/h3>\n

        Supervised by Anwar Edrees Salman<\/span><\/h3>\n

        Aim of study<\/span><\/h3>\n

        The offered introduction promoted to inspect the role of NLRP3 inflammasome in a sample of Iraqi children with celiac disease through the context of some serological, immunological and immunogenetic factors; therefore the following aims were planned:<\/span><\/h3>\n

        Assessing the levels of IL-1\u03b2 in the sera of celiac children and comparing it with the control group.<\/span><\/h3>\n

        \u00a0Determine the NLRP3 Inflammasome gene expression level by using Real time quantitative PCR technique (RT-qPCR<\/span><\/h3>\n

        Follow the relationship between age, sex, height, weight, immunological factors and gene expression levels of inflammasome proteins<\/span><\/h3>\n

        \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Summary<\/span><\/h3>\n

        Celiac disease (or so-called wheat allergy) is an autoimmune disorder which is characterized by chronic inflammation that essentially affects the small intestine and is caused by eating gluten-containing foods. A current study was designed to identify some of the immune and genetic aspects in Iraqi patients with celiac disease. The study included 30 samples of children diagnosed with the celiac disease (male and female), were between 3-15 years of age whom attended to the consulting clinic at the Central Children’s Hospital, the Private Nursing Hospital and the Specialized Center for Endocrinology and Diabetes\/ Al Kindi Hospital in Baghdad during the Period from August )2018( to March )2019(. They have been confirmed to be infected with celiac by serological examinations and intestinal endoscopy. In addition, the study included 20 healthy children with matched ages to patients, representing the control group who\u2019s randomly selected from children with a negative history of autoimmune diseases<\/span><\/h3>\n

        Based on general characteristics, histological, serological and molecular examination, the study has been reached the following findings<\/span><\/h3>\n

        . Incidence of disease was observed in children aged (5-9) and (10-14) by 40% and 50%, respectively, and the number of infected females was 18 (60%) more than male 12 (40%), and the result showed that there was no significant difference (P >0.05). The study showed that the mean of (BMI) in patients was (15.4\u00b12.2 Kg\/m2) compared to (18.2\u00b13.6 Kg\/m2) in control group with a high significant difference (P\u22640.05). Also in terms of weight, the mean of patients’weight was signi\ufb01cantly lower than the control (22.9\u00b17.2, 31.1\u00b111.6 Kg, respectively) (P\u22640.05). As for height, the highest average of patients was (120.8 \u00b116.8 cm) compared to the height in the control group (129.2 \u00b121.4 cm) with no significant difference (P>0.05).<\/span><\/h3>\n

        . The highest frequency of patients (73.3%) was noticed within the close relatives parents and followed by (26.7%) in non-relative parents with no significant differences (P>0.05). Also, the incidence of the disease in children with a family history of the diseases was much higher (66%) followed by children whose families were free of the diseases (33%) (P\u22640.05). As well as, the present result showed that there was a high incidence of celiac disease in children whose parents are relatives of the first degree, as well as in the children having a family history of genetic diseases especially; diabetes and thyroidism(53.3%, 6.7% respectively). The study showed a high percentage for diabetes (P\u22640.05), these results revealed a strong genetic link between diabetes and thyroidism with CD<\/span><\/h3>\n

        . Based on Marsh classification, results revealed that the majority of patients had partial villous atrophy (Marsh \u0428 A) of (70%), While that\u00a0\u00a0 percentage of children with subtotal and total villous atrophy (Marsh III B and III C) were lower than those with partial villous atrophy (13.3%, 16.7% respectively. Neither Marsh InorMarsh II was observed among study patients<\/span><\/h3>\n

        . The study showed that the highest mean of anti-gliadin IgA antibody in celiac patients (83.8\u00b1119.4 U\/ml)(P\u22640.05) as compared to control group (0.8\u00b10.4 U\/ml. Moreover, antibodies directed against tTGwas showed a high statistical significance between celiac patients and controls (349.3\u00b1556.1 and 0.9\u00b10.5 U\/ml respectively). However, no significant differences (P\u2265 0.05) of anti-gliadine IgA and anti-tTG were observed with different characteristics of the patients under study such as age, sex, body mass index (BMI), kinship between parents, family history of the diseases, chronic diseases in the family as well as marsh classification. It was interesting that anti-tTG IgA showed a high significant difference (P\u22640.05) with gradual increase in the level of intestinal damage classified by Marsh (Marsh IIIA, 202.5\u00b1345.6U\/ml; Marsh IIIB, 382.5\u00b1255.5 U\/ml and Marsh IIIC 939.4\u00b11022.8 U\/ml).Positive correlation was found between anti-tTG levels and modified Marsh grading<\/span><\/h3>\n

        . Results showed a slight increase in both IL-1\u03b2 serum level of celiac patients(82.7\u00b1179.4 pg\/ml) compared to controls (71.6\u00b151.5 pg\/ml) with no significant difference (P>0.05) and in the level of NLRP3 inflammasome gene expression in celiac patients (3.4\u00b110.5) as compared to control group (1.7\u00b11.8). The result showed that there was no statistical significant differences (P>0.05) were found between IL-1\u03b2 levels and NLRP3 inflammasome gene expression level with the studied characteristics of celiac patients.<\/span><\/h3>\n

        . ROC analysis showed high sensitivity and specificity of anti-gliad in IgA and anti-tTG in the serum of celiac patients (100%, 95 and 91.7%, 90% respectively), whereas the area under curve (AUC) of anti-gliad in was (0.99) normally higher than (AUC) for anti-tTG (0.95). Results suggest that there was no significant correlation between clinical parameters of patients in the study (P>0.05). There are no significant relationship between the IL-1\u03b2 serum level and the genetic expression of inflammatory proteins NLRP3inflammasome in celiac group, and that the relationship between the parameters \u00a0statistically was not significant.<\/span><\/h3>\n

        <\/h3>\n

         <\/p>\n

         <\/p>\n

         <\/p>\n

         <\/p>\n

         <\/p>\n

         <\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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