{"id":38448,"date":"2021-08-27T21:21:24","date_gmt":"2021-08-27T18:21:24","guid":{"rendered":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=38448"},"modified":"2021-09-02T21:42:04","modified_gmt":"2021-09-02T18:42:04","slug":"38448","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=38448","title":{"rendered":"\u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u062a\u0648\u0635\u0644 \u0627\u0644\u0649 \u0639\u0644\u0627\u0642\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u062d\u064a\u0648\u064a\u0629 \u0628\u064a\u0646 \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0648 \u0627\u0644\u0627\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646 38"},"content":{"rendered":"<h4 style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-38452\" 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\u0625\u0644\u0649 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0628\u064a\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0623\u0646\u0627\u062b \u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0628\u0639\u0636 \u0627\u0644\u0628\u0627\u0631\u0627\u0645\u064a\u062a\u0631\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u0648\u062d\u064a\u0648\u064a\u0629 \u0642\u0628\u0644 \u0648\u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c .\u00a0<\/span><\/h4>\n<hr \/>\n<h4 style=\"text-align: left;\"><span style=\"color: #000080;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/h4>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Interleukin-38 as a novel biochemical marker In Alzheimer`s disease patients in Iraq before and after treatment with Memantine<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">By Ayat Mahmood Yahya<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Supervised by Asst.prof.Dr.Rasha Zuhair Jassim<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The aim of the present study<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">and after treatment with memantine and taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To innovate a biochemical relationship between AD and IL-38 before and after treatment with memantine (i.e. examination of memantine action on IL-38) and taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To submit new concepts regarding albumin in AD patients before and after treatment with memantine and also taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To suggest a new explanation regarding hemoglobin in AD patients before and after treatment with memantine taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To expose a specific relationship between AD and ornithine before and after treatment with memantine taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To highlight the similarities and differences between the present study and other previous AD studies regarding TSH before and after treatment with memantine taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">To highlight the similarities and differences between the present study and other previous AD studies concerning lipid profile before and after treatment with memantine taking into account the gender<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Conclusions<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study provides a definite clarification for higher levels of A\u03b2 in AD patients by a detailed mechanism based on both protein misfolding and inflammatory responses of glial cells<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study is the first reporting that IL-38 is a novel biochemical marker for AD<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study is the first elucidating and clarifying memantine action on IL-38 in AD patients by highlighting the interaction between inflammatory mediators and inflammatory regulators<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study submits a unique detailed explanation regarding albumin level in AD patients before and after treatment with memantine.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study gives a comprehensive mechanism regarding lower levels of hemoglobin in AD patients based on anemia of chronic diseases and also highlights the role of iron retention caused by anemia of chronic diseases<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study submits a definite mechanism regarding higher levels of ornithine in AD patients based on inflammatory responses<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study is the first submitting novel mechanism regarding memantine action on ornithine level in AD patients<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study supports previous and recent studies regarding lower levels of (TSH and HDL ) and higher levels of (TC , TG , LDL and VLDL) in AD patients.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The biochemical action of memantine on A\u03b2 and IL-38 and TC levels is more potent on males than females.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The biochemical action of memantine on Albumin , hemoglobin , ornithine , TSH , TG , HDL , LDL , and VLDL levels is approximately the same in both males and females.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The levels of (A\u03b2 , IL-38 , ornithine , TSH , TC , TG , HDL , LDL and VLDL ) in untreated AD patients are minimally influenced by the gender.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The levels of both albumin and hemoglobin in untreated AD patients are influenced by the gender.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The present study supports all previous and recent studies in accordance with anti-inflammatory characteristics of IL-38 and also exposes novel concepts to the clinical biochemistry in accordance with IL-38 , A\u03b2 , albumin , hemoglobin and ornithine.\u00a0<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Recommendations and future work<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Checking up the level of A\u03b2 in sera of healthy persons (from 40 years old and up) to detect any abnormal changes<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">The biochemical \/ clinical importance of IL-38 in AD must be highlighted , for example : determination of its level in cerebrospinal fluid.\u00a0<\/span><\/h3>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #000080;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/h4>\n<h4 style=\"text-align: justify;\"><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>\u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 (\u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645) \u0631\u0633\u0627\u0644\u0629 \u0627\u0644\u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 (\u0627\u0644\u0627\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646 38&#8230;.<a class=\"cz_readmore\" href=\"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=38448\"><i class=\"fa fa-angle-left\" aria-hidden=\"true\"><\/i><span>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":25,"featured_media":38451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[44,7,59,16],"tags":[23,47],"class_list":["post-38448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-44","category-7","category-59","category-16","tag-ihcoedu","tag-chem"],"modified_by":"ihcoedu","_links":{"self":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/38448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38448"}],"version-history":[{"count":0,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/38448\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/38451"}],"wp:attachment":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=38448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=38448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}