{"id":44440,"date":"2022-06-16T21:41:14","date_gmt":"2022-06-16T18:41:14","guid":{"rendered":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=44440"},"modified":"2023-06-28T18:25:16","modified_gmt":"2023-06-28T15:25:16","slug":"%d9%82%d8%b3%d9%85-%d8%a7%d9%84%d9%83%d9%8a%d9%85%d9%8a%d8%a7-%d9%8a%d9%86%d8%a7%d9%82%d8%b4-%d8%b1%d8%b3%d8%a7%d9%84%d8%a9-%d9%85%d8%a7%d8%ac%d8%b3%d8%aa%d9%8a%d8%b1-%d8%aa%d8%a8%d8%ad%d8%ab-%d9%81","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=44440","title":{"rendered":"\u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u0628\u062d\u062b \u0641\u064a \u062a\u062e\u0644\u064a\u0642 \u0645\u0631\u0643\u0628\u0627\u062a \u062d\u0644\u0642\u064a\u0629 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u062c\u062f\u064a\u062f\u0629 \u0648\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0646\u0634\u0627\u0637 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style=\"color: #000080;\">\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u062b\u0627\u0644\u062b: \u0648\u064a\u062a\u0636\u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0642\u0648\u0627\u0639\u062f \u0634\u064a\u0641 \u0645\u0639:\u00a0[2- \u062d\u0645\u0636 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0628\u064a\u0646\u0632\u0648\u064a\u0643 (14) \u060c 2- \u062d\u0645\u0636 \u0623\u0645\u064a\u0646\u0648\u0628\u0646\u0632\u0648\u064a\u0643 (12\u060c13)].<\/span><\/h4>\n<h4 style=\"text-align: justify;\"><span style=\"color: #000080;\">\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0631\u0627\u0628\u0639: &#8211; \u064a\u062a\u0636\u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u0632\u0621 \u062a\u062e\u0644\u064a\u0642 \u0645\u0631\u0643\u0628 \u0627\u0648\u0643\u0633\u064a\u062f\u0627\u0632\u0648\u0644 1\u060c 3\u060c 4 (17) \u062b\u0645 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\u0623\u0646\u0647\u064a\u062f\u0631\u064a\u062f \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0623\u0648\u0643\u0633\u0627\u0632\u064a\u0628\u0627\u0646\u0627\u062a:\u00a0[\u0645\u0627\u0644\u064a\u0643 \u0623\u0646\u0647\u064a\u062f\u0631\u064a\u062f (28\u060c29) \u060c \u0641\u062b\u0627\u0644\u064a\u0643 \u0623\u0646\u0647\u064a\u062f\u0631\u064a\u062f (26\u060c27) \u060c \u0623\u0646\u0647\u064a\u062f\u0631\u064a\u062f \u0633\u0643\u0633\u064a\u0646\u064a\u0643 (22-25) \u060c 3-\u0646\u064a\u062a\u0631\u0648 \u0641\u062b\u0627\u0644\u064a\u0643 \u0623\u0646\u0647\u064a\u062f\u0631\u064a\u062f .<\/span><\/h4>\n<h4 style=\"text-align: justify;\"><span style=\"color: #000080;\">\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0633\u0627\u062f\u0633: \u064a\u0634\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u062c\u0632\u0621 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0644\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u0635\u0646\u0639\u0629. \u062a\u0645 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0634\u0637\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0646\u0634\u0631 \u0627\u0644\u062c\u064a\u062f\u0629 \u0636\u062f \u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u0627\u0644\u0633\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0623\u0645\u0631\u0627\u0636. <em>\u0628\u0643\u062a\u064a\u0631\u064a\u0627<\/em><em> Staphylococcus aureus (G +). <\/em><em>\u060c <\/em><em>Enterobacter cloacae (G-).<\/em><\/span><\/h4>\n<h4 style=\"text-align: justify;\"><span style=\"color: #000080;\">. \u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0623\u0646 \u0628\u0639\u0636 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0642\u062f \u062d\u0642\u0642\u062a \u0646\u0634\u0627\u0637\u064b\u0627 \u0642\u0627\u0628\u0644\u0627\u064b \u0644\u0644\u0642\u064a\u0627\u0633.<\/span><\/h4>\n<hr \/>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Synthesis of new heterocyclic compounds and evaluating the biological activity for some of them<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">By Mays Neama Mohammed<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Supervisor by prof.Dr.Ibtisam K.Jasim<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Aim of the work<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">\u00a0\u00a0 The aim of the current worke of this thesis is to investigate synthesis of a new number of different derivatives of heterocyclic compounds and determine the antibacterial activity against some types of bacterial including Gram (+) and Gram (-) The new compounds involving\u00a0<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">-Synthesis of five membered heterocyclic compounds .<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">-Synthesis of seven\u00a0 membered heterocyclic compounds .<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">-Synthesis of new Schiff base .<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">-The five membered heterocyclic compounds including tetrazole ,thiazalididine ,besides preparing of 2-amino thiadiazole and 2amino oxadiazole.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Abstract<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">This work in valves preparation1, 3 ,4-oxadiazole and 1,3,4-thiodiazole<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Where the work was divided into seven different parts:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">First part: This part includes synthesis of 1 ,3, 4-thiadiazol compound (3) then treatment this compound with:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">[4-Nitro Benzaldehyde,4- Chloro Benzaldehyd,4-dimethylaminobenzaldehyde ,4-Methoxy benzaldehyde].<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">to get Schiff base(4-7), scheme I<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Second part: This part includes treatment Schiff bases with:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">[ NaN3 to get tetrazole (8,9),chloro acetyl chloride(10,11) and TEA,thioglycolic acid(12)]<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">.scheme II.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Third part: this part includes treatmentSchiff bases with:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">[2- hydroxybenzoic acid (14),2- aminobenzoic acid(12,13)]. scheme III<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Fourth part: -This part includes synthesis of 1 ,3, 4-oxidiazol compound (17) then treatment:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">[4-bromo benzaldehyde,4-Nitro benzaldehyde,4-Methoxy benzaldehyde,4-dimethylaminobenzaldehyde]<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">to get Schiff base[18-21], scheme IV.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Fifth part: This part includes treatment Schiff bases with:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">\u00a0anhydrides to get oxazepanes:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">[ maleic anhydride(28,29) ,phthalic anhydride(26,27), succinic anhydride(22-25), 3-nitro phthalic anhydride(30,31)]. scheme V.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Sixth part:This part includes the study at anti-bacterial activities of some manufactured compounds. These activates were identified in vitro using good publishing method against two types of pathogenic strains.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">. bacteria Staphylococcus aureus (G+).<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">., Enterobacter cloacae(G-).<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">. The result was obtained that some of these compounds realized measurable activity.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">Future work suggestions:<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">1- The formation of liquid crystalline proparties for the produced compounds is investigated.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">&#8211; Research into the toxicity of these derivatives.<\/span><\/h3>\n<h3 style=\"text-align: left;\"><span style=\"color: #993366;\">&#8211; In vivo investigation of biological activities.<\/span><\/h3>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 (\u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645) \u0631\u0633\u0627\u0644\u0629 \u0627\u0644\u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 &#8220;\u062a\u062e\u0644\u064a\u0642 \u0645\u0631\u0643\u0628\u0627\u062a \u062d\u0644\u0642\u064a\u0629 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u062c\u062f\u064a\u062f\u0629 \u0648\u062a\u0642\u064a\u064a\u0645&#8230;.<a class=\"cz_readmore\" href=\"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=44440\"><i class=\"fa fa-angle-left\" aria-hidden=\"true\"><\/i><span>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":25,"featured_media":44443,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[7,59,68,98,16],"tags":[61,47],"class_list":["post-44440","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7","category-59","category-68","category-98","category-16","tag-61","tag-chem"],"modified_by":"ihcoedu","_links":{"self":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/44440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44440"}],"version-history":[{"count":0,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/44440\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/44443"}],"wp:attachment":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}