{"id":45026,"date":"2022-08-22T08:33:16","date_gmt":"2022-08-22T05:33:16","guid":{"rendered":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=45026"},"modified":"2023-06-28T01:27:48","modified_gmt":"2023-06-27T22:27:48","slug":"%d9%82%d8%b3%d9%85-%d8%a7%d9%84%d9%83%d9%8a%d9%85%d9%8a%d8%a7%d8%a1-%d9%8a%d9%86%d8%a7%d9%82%d8%b4-%d8%b1%d8%b3%d8%a7%d9%84%d8%a9-%d9%85%d8%a7%d8%ac%d8%b3%d8%aa%d9%8a%d8%b1-%d8%aa%d8%ad%d8%b6%d8%b1-9","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=45026","title":{"rendered":"\u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u064a\u0646\u0627\u0642\u0634 \u0631\u0633\u0627\u0644\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u062a\u062d\u0636\u0631 \u0639\u062f\u062f \u062c\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062d\u0644\u0642\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0625\u0628\u062a\u062f\u0621\u0627 \u0645\u0646 \u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0648\u062a\u0642\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627 \u0636\u062f \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a"},"content":{"rendered":"

\"\"<\/h4>\n

\u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 (\u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645) \u0631\u0633\u0627\u0644\u0629 \u0627\u0644\u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 ” \u062a\u062d\u0636\u064a\u0631<\/strong> \u0648\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0644\u0639\u062f\u062f \u062c\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062d\u0644\u0642\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0645\u0628\u062a\u062f\u0623 \u0645\u0646 \u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 ” \u0644\u0644\u0637\u0627\u0644\u0628 ”\u00a0<\/strong>\u0639\u0628\u0627\u0633 \u062d\u0633\u0646 \u0635\u062e\u064a\u0644<\/strong> ” \u0627\u0644\u062a\u064a \u0627\u0646\u062c\u0632\u0647\u0627 \u062a\u062d\u062a \u0627\u0634\u0631\u0627\u0641 \u0627\u0644\u062a\u062f\u0631\u064a\u0633\u064a\u0629 \u0641\u064a \u0627\u0644\u0642\u0633\u0645 ”\u00a0<\/strong>\u0623.\u0645.\u062f. \u0631\u0633\u0645\u064a\u0629 \u0645\u062d\u0645\u0648\u062f \u0631\u0645\u064a\u0632 ” \u0648\u0646\u0648\u0642\u0634\u062a \u0645\u0646 \u0642\u0628\u0644 \u0627\u0639\u0636\u0627\u0621 \u0644\u062c\u0646\u0629 \u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 \u0627\u0644\u0645\u0628\u064a\u0646\u0629 \u0627\u0633\u0645\u0627\u0626\u0647\u0645 \u0641\u064a \u0645\u0627 \u064a\u0623\u062a\u064a :<\/strong><\/span><\/h4>\n
    \n
  • \n

    \u0623\u062f. \u0627\u0628\u062a\u0633\u0627\u0645 \u062e\u0644\u064a\u0641\u0629 \u062c\u0627\u0633\u0645 – \u0631\u0626\u064a\u0633\u0627<\/span><\/h4>\n<\/li>\n
  • \n

    \u0623.\u0645.\u062f. \u0627\u062d\u0645\u062f \u0645\u062a\u0646\u0628\u064a \u0639\u0628\u062f \u0627\u0644\u0644\u0647 – \u0639\u0636\u0648\u0627<\/span><\/h4>\n<\/li>\n
  • \n

    \u0623.\u0645.\u062f. \u0631\u0627\u0626\u062f \u0634\u0627\u0643\u0631 \u0645\u0635\u0637\u0641\u0649 – \u0639\u0636\u0648\u0627<\/span><\/h4>\n<\/li>\n
  • \n

    \u0623.\u0645.\u062f. \u0631\u0633\u0645\u064a\u0629 \u0645\u062d\u0645\u0648\u062f \u0631\u0645\u064a\u0632 – \u0639\u0636\u0648\u0627 \u0648 \u0645\u0634\u0631\u0641\u0627<\/span><\/h4>\n<\/li>\n<\/ul>\n

    <\/h4>\n

    \u0648\u064a\u0647\u062f\u0641 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0649 \u062d\u0636\u064a\u0631 \u0628\u0639\u0636 \u0627\u0644\u0645\u0634\u062a\u0642\u0627\u062a \u0644\u0647\u0630\u0627 \u0627\u0644\u062d\u0627\u0645\u0636 \u0628\u0639\u062f\u0629 \u0637\u0631\u0642. \u0647\u0630\u0627 \u0627\u0644\u0639\u0645\u0644 \u064a\u062a\u0636\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 \u0645\u0631\u0643\u0628\u0627\u062a \u062d\u0644\u0642\u064a\u0629 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646\u064a\u0643 \u0643\u0648\u0646 \u00a0\u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646\u064a\u0643 \u0648\u0645\u0634\u062a\u0642\u0627\u062a\u0647 \u064a\u0639\u062a\u0628\u0631 \u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u0647\u0645\u0629 \u062c\u062f\u064b\u0627 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a. \u0644\u0630\u0644\u0643 \u062a\u0645 \u062a<\/span><\/h4>\n

    \u0648\u062a\u0636\u0645\u0646\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0627\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0627\u062a\u064a\u0629 :<\/span><\/h4>\n
      \n
    1. \n

      \u064a\u062a\u0636\u0645\u0646 \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0627\u0648\u0644 \u062a\u062d\u0636\u064a\u0631\u0627\u0644\u062a\u0631\u0627\u064a\u0627\u0632\u0648\u0644 (5) \u0645\u0646 \u0639\u062f\u0629 \u062e\u0637\u0648\u0627\u062a. \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u0627\u0648\u0644\u0649 \u0647\u064a \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0631 (2) \u0628\u062a\u0641\u0627\u0639\u0644 \u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646\u064a\u0643 \u0645\u0639 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0628\u0648\u062c\u0648\u062f \u062d\u0627\u0645\u0636 \u0627\u0644\u0643\u0628\u0631\u064a\u062a\u064a\u0643 \u0627\u0644\u0645\u0631\u0643\u0632. \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0631\u0643\u0628 (2) \u0645\u0639 \u0627\u0644\u0647\u0627\u064a\u062f\u0631\u0627\u0632\u064a\u0646 \u0627\u0644\u0645\u0627\u0626\u064a \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u064a\u0639\u0637\u064a \u0627\u0644\u0645\u0631\u0643\u0628 \u0631\u0642\u0645 (3) \u0627\u0644\u0630\u064a \u0647\u0648 \u062d\u0627\u0645\u0636 \u0627\u0644\u0647\u0627\u064a\u062f\u0631\u0627\u0632\u0627\u064a\u062f. \u0627\u0644\u0630\u064a \u0628\u062f\u0648\u0631\u0647 \u064a\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0641\u0646\u064a\u0644 \u0627\u064a\u0632\u0648\u062b\u0627\u064a\u0648\u0633\u064a\u0627\u0646\u0627\u062a \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u0644\u064a\u0639\u0637\u064a \u0627\u0644\u0645\u0631\u0643\u0628 \u0631\u0642\u0645 (4) \u0627\u0644\u0630\u064a \u0647\u0648 \u0627\u0644\u062b\u0627\u064a\u0648\u0633\u064a\u0645\u064a\u0643\u0627\u0631\u0628\u0627\u0632\u0627\u064a\u062f. \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u0627\u062e\u064a\u0631\u0629 \u0647\u064a \u0627\u0644\u063a\u0644\u0642 \u0627\u0644\u062d\u0644\u0642\u064a \u0644\u0644\u0645\u0631\u0643\u0628 \u0631\u0642\u0645 (4) \u0628\u0648\u062c\u0648\u062f \u0642\u0627\u0639\u062f\u0629 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u062f \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0644\u064a\u0639\u0637\u064a \u0627\u0644\u0645\u0631\u0643\u0628 (5) (4-phenyl-5-(pyridin-3-yl)-4H<\/em>-1,2,4-triazole-3-thiol).<\/span><\/h4>\n<\/li>\n
    2. \n

      \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u062b\u0627\u0646\u064a \u064a\u062a\u0636\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062b\u0627\u064a\u0648\u0627\u064a\u062b\u0631 (6a,6b,6c) \u0628\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0631\u0643\u0628 \u0631\u0642\u0645 (5) \u0645\u0639 \u0647\u0627\u0644\u064a\u062f\u0627\u062a \u0627\u0644\u0643\u064a\u0644 \u0645\u062e\u062a\u0644\u0641\u0629 (1- \u0628\u0631\u0648\u0645\u0648\u0628\u0631\u0648\u0628\u0627\u0646, 1- \u0628\u0631\u0648\u0645\u0648\u0628\u064a\u0648\u062a\u0627\u0646 \u0648\u0628\u0631\u0648\u0645\u064a\u062f \u0627\u0644\u0628\u0646\u0632\u0627\u064a\u0644) \u0641\u064a \u0648\u0633\u0637 \u0642\u0627\u0639\u062f\u064a \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u062f\u0627\u064a\u0648\u0643\u0633\u0627\u0646 \u0643\u0645\u0630\u064a\u0628.<\/span><\/h4>\n<\/li>\n
    3. \n

      \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u062b\u0627\u0644\u062b \u064a\u062a\u0636\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0633\u0644\u0641\u0648\u0646\u064a\u0644 (7a,7b,7c) \u0628\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062b\u0627\u064a\u0648\u0627\u064a\u062b\u0631 (6a,6b,6c) \u0645\u0639 \u0628\u0631\u0645\u0646\u0643\u0646\u0627\u062a \u0627\u0644\u0628\u0648\u062a\u0627\u0633\u064a\u0648\u0645 \u0628\u0648\u062c\u0648\u062f \u062d\u0627\u0645\u0636 \u0627\u0644\u062e\u0644\u064a\u0643 \u0627\u0644\u062b\u0644\u062c\u064a.<\/span><\/h4>\n<\/li>\n
    4. \n

      \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0631\u0627\u0628\u0639 \u064a\u062a\u0636\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 \u0642\u0648\u0627\u0639\u062f \u0634\u0641 (10d,10e,10f,10g,10h) \u0645\u0646 \u0639\u062f\u0629 \u062e\u0637\u0648\u0627\u062a. \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u0627\u0648\u0644\u0649 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u062d\u0627\u0645\u0636 (8) \u0628\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062a\u0631\u0627\u064a\u0627\u0632\u0648\u0644 (5) \u0645\u0639 \u0643\u0644\u0648\u0631\u0648\u062d\u0627\u0645\u0636 \u0627\u0644\u062e\u0644\u064a\u0643 \u0628\u0648\u062c\u0648\u062f \u0643\u0627\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0643\u0648\u0633\u0637 \u0642\u0627\u0639\u062f\u064a. \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0631\u0643\u0628 (8) \u0645\u0639 \u0627\u0644\u062b\u0627\u064a\u0648\u0633\u064a\u0645\u064a\u0643\u0627\u0631\u0628\u0627\u0632\u0627\u064a\u062f \u0628\u0648\u062c\u0648\u062f \u0643\u0644\u0648\u0631\u064a\u062f \u0627\u0644\u0641\u0648\u0633\u0641\u0648\u0631\u064a\u0644 \u0644\u064a\u0639\u0637\u064a \u0627\u0644\u062b\u0627\u064a\u0627\u062f\u0627\u064a\u0627\u0632\u0648\u0644 (9) \u0627\u0644\u0630\u064a \u0628\u062f\u0648\u0631\u0647 \u064a\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0627\u0644\u0627\u0644\u062f\u064a\u0647\u0627\u064a\u062f \u0628\u0648\u062c\u0648\u062f \u0642\u0637\u0631\u0627\u062a \u0645\u0646 \u062d\u0627\u0645\u0636 \u0627\u0644\u062e\u0644\u064a\u0643 \u0627\u0644\u062b\u0644\u062c\u064a \u0645\u0639 \u0627\u0644\u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u0643\u0645\u0630\u064a\u0628 \u0644\u064a\u0639\u0637\u064a \u0642\u0648\u0627\u0639\u062f \u0634\u0641.<\/span><\/h4>\n<\/li>\n
    5. \n

      \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0631\u0627\u0628\u0639 \u064a\u062a\u0636\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062b\u0627\u064a\u0648\u0632\u0648\u0644\u062f\u064a\u0646-4-\u0648\u0646 (11d,11e,11f,11g,11h)\u060c \u0648\u0630\u0644\u0643 \u0628\u062a\u0641\u0627\u0639\u0644 \u0642\u0648\u0627\u0639\u062f \u0634\u0641 (10d,10e,10f,10g,10h) \u0645\u0639 \u0645\u0631\u0643\u0628\u062a\u0648 \u062d\u0627\u0645\u0636 \u0627\u0644\u062e\u0644\u064a\u0643 \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0646\u0632\u064a\u0646 \u0643\u0645\u0630\u064a\u0628 \u0644\u064a\u0639\u0637\u064a \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062b\u0627\u064a\u0648\u0632\u0648\u0644\u062f\u064a\u0646-4-\u0648\u0646.<\/span><\/h4>\n<\/li>\n
    6. \n

      \u062a\u0645 \u062a\u0645\u064a\u064a\u0632 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0642\u0627\u0637 \u0627\u0644\u0627\u0646\u0635\u0647\u0627\u0631 \u0648\u0623\u0637\u064a\u0627\u0641 FT-IR \u0648\u0628\u0639\u0636\u0647\u0627 \u0628\u0648\u0627\u0633\u0637\u0629 1<\/sup>H-NMR \u0648\u0623\u0637\u064a\u0627\u0641 \u0627\u0644\u0643\u062a\u0644\u0629.<\/span><\/h4>\n<\/li>\n
    7. \n

      \u062a\u0645 \u0641\u062d\u0635 \u0628\u0639\u0636 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0643\u0634\u0641 \u0639\u0646 \u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0631\u0628\u0639\u0629 \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u0645\u0631\u0636\u064a\u0629\u060c \u0648\u0647\u064a (Escherichia coli<\/em> \u0648(Klebsiella sp<\/em>ecies (-(G \u0648 (Staphylococcus aureus<\/em> \u0648(Staphylococcus epidermidis<\/em> (+(G \u0648\u0646\u0648\u0639 \u0648\u0627\u062d\u062f \u0645\u0646 \u0627\u0644\u0641\u0637\u0631\u064a\u0627\u062a (Candida albicans<\/em>).<\/span><\/h4>\n
      \n<\/li>\n<\/ol>\n

      Synthesis and Evaluation of Antimicrobial Activity of Some New Heterocyclic Compounds Starting from Nicotinic acid<\/span><\/h3>\n

      By Abbas Hasan Sakhil Matrood<\/span><\/h3>\n

      \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Supervised By<\/span><\/h3>\n

      Assist. Prof. Dr. Rasmia Mahmood Rumez<\/span><\/h3>\n

      Aim of the work<\/span><\/h3>\n

      Nicotinic acid induce researchers for further developments in organic synthesis because of their biological activity.<\/span><\/h3>\n

      This work includes<\/span><\/h3>\n

      Synthesis of 1,2,4-triazole compound derivedfrom nicotinic acid.<\/span><\/h3>\n

      The following derivatives synthesized from 1,2,4-triazole compound:<\/span><\/h3>\n
        \n
      1. \n

        Synthesis of thioethers.<\/span><\/h3>\n<\/li>\n
      2. \n

        Synthesis of sulfonyl compounds.<\/span><\/h3>\n<\/li>\n
      3. \n

        Synthesis of amine compound containing thiadiazole ring.<\/span><\/h3>\n<\/li>\n
      4. \n

        Synthesis of Schiff bases.<\/span><\/h3>\n<\/li>\n
      5. \n

        Synthesis of 1,3-thiazolidin-4-one compounds.<\/span><\/h3>\n<\/li>\n<\/ol>\n

        3) Screening of biological activity for synthesized compounds against four kinds of bacteria (G+ and G-) and one kind of fungi<\/span><\/h3>\n

        Abstract<\/span><\/h3>\n

        Nicotinic acid, and its derivatives are very important compounds used in different field such as biological activity. Therefore some compounds have been synthesized by many methods. This work is divided into different five parts, Scheme (I)<\/span><\/h3>\n
          \n
        1. \n

          The first route includes prepared of triazole (5) from several steps. The first step is prepared the ester (2) by reacted of nicotinic acid with MeOH in presence conc. H2SO4. Reaction of the ester (2) with hydrazine hydrate in EtOH to formed the acid hydrazide (3), which was reacted with phenyl isothiocyanate in ethanol as a solvent to give thiosemicarbazide (4). Finally ring closure of thiosemicarbazide (4) in the presence of NaOH(4N) to afford<\/span><\/h3>\n<\/li>\n<\/ol>\n

          triazole (4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol) (5)<\/span><\/h3>\n

          . The second route includes synthesis of thioether compounds (6a-b) by reaction triazole (5) with different alkyl halide (1-bromopropane, 1-bromobutane, benzyl bromide) in alkaline medium and dioxane as a solvent<\/span><\/h3>\n

          .The third route includes synthesis of sulfonyl compounds (7a-c) by reaction of thioether (6a-c) with potassium permanganate in glacial acetic acid.<\/span><\/h3>\n

          .The forth route includes synthesis Schiff bases (10d-h) via several steps. The first step was prepared the acid (8)by reacted of triazole (5) with chloroacetic acid in presence of Na2CO3. Reaction of the acid (8) with thiosemicarbazide in POCl3 to formation the thiadiazole (9), which was reacted with aldehydes (benzaldehyde, 4-chlorobenzaldehyde, 4-N,N-dimethylbenzaldehyde, 4-hydroxybenzaldehyde and 4-nitrobenzaldehyde in presence of drops of glacial acetic acid with ethanol as a solvent to give Schiff bases<\/span><\/h3>\n

          .The fifth route includes synthesis of thiazoldin-4-one compounds (11d-h) by reaction of Schiff bases (10d-h) with mercaptoacetic acid in benzene to give thiozoldin-4-one compounds<\/span><\/h3>\n

          . All compounds were characterized by used melting points, FT-IR spectra and some of them via 1H-NMR and mass spectra\u00a0<\/span><\/h3>\n

          . Some of these new compounds have been screened for their antimicrobial efficiencies, using four types of pathological bacteria, the (Escherichia coli and Klebsiella species)\u00a0 (G-) and (Staphylococcus aureusand Staphylococcusepidermidis) (G+) and one kind of fungi (Candidaalbicans)<\/span><\/h3>\n

           <\/p>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          \u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 (\u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645) \u0631\u0633\u0627\u0644\u0629 \u0627\u0644\u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 ” \u062a\u062d\u0636\u064a\u0631….<\/i>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":25,"featured_media":45031,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[7,59,68,98,16],"tags":[23,61,47],"class_list":["post-45026","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7","category-59","category-68","category-98","category-16","tag-ihcoedu","tag-61","tag-chem"],"modified_by":"ihcoedu","_links":{"self":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/45026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45026"}],"version-history":[{"count":0,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/45026\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/45031"}],"wp:attachment":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}