{"id":53477,"date":"2023-10-01T13:36:51","date_gmt":"2023-10-01T10:36:51","guid":{"rendered":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=53477"},"modified":"2023-10-02T09:00:34","modified_gmt":"2023-10-02T06:00:34","slug":"%d8%a3%d8%b7%d8%b1%d9%88%d8%ad%d8%a9-%d8%af%d9%83%d8%aa%d9%88%d8%b1%d8%a7%d9%87-%d8%aa%d9%82%d9%8a%d9%91%d9%85-%d8%a8%d8%b9%d8%b6-%d8%a7%d9%84%d9%85%d8%b9%d9%84%d9%85%d8%a7%d8%aa-%d8%a7%d9%84%d9%85","status":"publish","type":"post","link":"https:\/\/ihcoedu.uobaghdad.edu.iq\/?p=53477","title":{"rendered":"\u0623\u0637\u0631\u0648\u062d\u0629 \u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u062a\u0642\u064a\u0651\u0645 \u0628\u0639\u0636 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0639\u0631\u0627\u0642\u064a\u064a\u0646 \u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0627\u0644\u0630\u0626\u0628 \u0627\u0644\u0627\u062d\u0645\u0631\u0627\u0631\u064a"},"content":{"rendered":"

 <\/p>\n

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1- \u062a\u0642\u064a\u064a\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0629 (ANA & anti-dsDNA) \u0641\u064a \u0627\u0644\u062f\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 ELISA.<\/strong><\/p>\n

2- \u062a\u0642\u062f\u064a\u0631 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0640 RANKL \u0648 Sclerostin \u0641\u064a \u0645\u0635\u0644 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0648\u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 ELISA.<\/strong><\/p>\n

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5- \u062a\u0642\u062f\u064a\u0631 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u0646\u0632\u0631\u0629 Zn \u0648Cu \u0648Al \u0648\u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a Ca \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0630\u0631\u064a.<\/strong><\/p>\n

6- \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0639\u0644\u0627\u062c (Prednisone\u00a0 + hydroxychloroquine + vitamin D3) \u0648\u062a\u0623\u062b\u064a\u0631\u0647 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0642\u0627\u0633\u0629.<\/strong><\/p>\n

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\u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a \u0641\u064a \u0645\u062f\u064a\u0646\u0629 \u0628\u063a\u062f\u0627\u062f \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0629 \u0645\u0646 \u0622\u0630\u0627\u0631 2022 \u062d\u062a\u0649 \u0622\u0628 2022. \u0633\u064f\u062d\u0628 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0644\u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0645\u0646\u0634\u0637 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0648\u0648\u064a \u0643\u0627\u0628\u0627- \u0628\u064a RANKL\u060c \u0627\u0644\u0633\u0643\u0644\u0631\u0648\u0633\u062a\u064a\u0646 Sclerostin\u060c \u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c PD-1 \u0648\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D3 Vitamin D3 \u0628\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0625\u0645\u062a\u0635\u0627\u0635\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 ELISA\u060c \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u062c\u064a\u0646 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c PDCD1<\/em> \u0648\u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0646\u0634\u0637\u0629 \u00a0NFATc1\u0628\u062a\u0642\u0646\u064a\u0629 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u0631\u064a\u0632 \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644 \u0628\u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u062d\u0642\u064a\u0642\u064a Real time-qPCR\u060c \u0641\u0636\u0644\u0627\u064b \u0639\u0646 \u062a\u0642\u062f\u064a\u0631 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0628\u0639\u0636 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u0646\u0632\u0631\u0629 \u0648\u0647\u064a \u0627\u0644\u0632\u0646\u0643 ((Zn\u060c \u0627\u0644\u0646\u062d\u0627\u0633 ((Cu \u0648\u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 (Al) \u0648\u0627\u0644\u0639\u0646\u0635\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 ((Ca \u0628\u0625\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 \u0645\u0637\u064a\u0627\u0641\u064a\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0630\u0631\u064a AAS.<\/strong><\/p>\n

\u0644\u0645 \u062a\u064f\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 \u062d\u0633\u0628 \u0627\u0644\u0639\u0645\u0631 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0627\u0645\u064a\u0639 \u0627\u0644\u062b\u0644\u0627\u062b \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/strong><\/p>\n

\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0623\u0646 \u0645\u0633\u062a\u0648\u0649 ANA \u0632\u0627\u062f \u0645\u0639\u0646\u0648\u064a\u0627\u064b (P\u22640.05) \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (G1 \u0648G2) \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c ((3.13\u00b10.26\u060c (2.37\u00b10.24) \u0648((0.504\u00b10.05 U\/ml \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0643\u0630\u0644\u0643 \u0627\u0631\u062a\u0641\u0639 \u0645\u0633\u062a\u0648\u0649 anti-dsDNA \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (G1 \u0648G2) \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c ((75.85\u00b17.67\u060c (59.72\u00b18.35) \u0648(22.12\u00b11.35) ng\/ml\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u0646\u0648\u064a \u0641\u064a \u0645\u0633\u062a\u0648\u0649 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D3 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (G1 \u0648G2) \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c\u00a0 ((56.87\u00b14.45\u060c (56.62\u00b12.08) \u0648(46.02\u00b11.57) ng\/ml\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0643\u0627\u0646 \u0645\u0633\u062a\u0648\u0649 PD-1 \u0645\u0631\u062a\u0641\u0639\u0627\u064b \u0623\u064a\u0636\u0627\u064b \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (G1 \u0648G2)\u00a0 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3\u060c \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c ((0.611\u00b10.04\u060c (0.579\u00b10.07) \u0648(0.256\u00b10.04) ng\/ml\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/strong><\/p>\n

\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0645\u0635\u0644 RANKL \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0645\u0639\u0646\u0648\u064a\u0629 (P\u22640.05) \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0627\u0645\u064a\u0639 \u0627\u0644\u062b\u0644\u0627\u062b \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629G2 \u060cG1 \u00a0\u0648G3\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c ((1.203\u00b10.29\u060c (0.921\u00b10.28) \u0648(0.870\u00b10.23) pg\/ml\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0643\u0630\u0644\u0643 \u0644\u0645 \u062a\u0633\u062c\u0644 \u0645\u0633\u062a\u0648\u064a\u0627\u062a Sclerostin \u0641\u0631\u0648\u0642\u0627\u064b \u0645\u0639\u0646\u0648\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0627\u0645\u064a\u0639 \u0627\u0644\u062b\u0644\u0627\u062b \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 G1\u060c G2 \u0648G3\u060c ((0.686\u00b10.09\u060c (0.588\u00b10.09) \u0648(0.462\u00b10.08 ) ng\/ml\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/strong><\/p>\n

\u0623\u0645\u0627 \u0639\u0646 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u060c \u0628\u064a\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u0646\u0648\u064a (P\u22640.05) \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a PDCD1<\/em> \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u064a\u0646 G2 (59.74\u00b133.26 folds)\u00a0 \u062a\u0644\u062a\u0647\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0628\u0643\u0631 G1 (23.18\u00b110.17 folds) \u060c\u00a0 \u062b\u0645 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 (3.46\u00b11.93) G3. \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0628\u064a\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u0646\u0648\u064a \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646 NFATc1 \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u064a\u0646 G3 (0.17\u00b10.16) \u062a\u0644\u062a\u0647\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0628\u0643\u0631 G1 (0.003\u00b10.002) \u062b\u0645 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3 (0.001\u00b10.0007).<\/strong><\/p>\n

\u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c Zn\u060c Cu\u060c Al \u0648Ca \u0623\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a Zn \u0648Ca \u0627\u0646\u062e\u0641\u0636\u062a \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 G1 \u0648 G2 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c (7.65\u00b10.09, 72.91\u00b11.22) \u0648(7.71\u00b10.12, 72.86\u00b11.31) \u00a0mg\/dl \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a\u060c \u0628\u064a\u0646\u0645\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 G3 \u0633\u062c\u0644\u062a ( 100.2\u00b12.36\u0648(9.22\u00b10.07 \u00a0mg\/dl \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0641\u064a \u062d\u064a\u0646 \u0633\u062c\u0644\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0646\u062d\u0627\u0633 \u0648\u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0627\u0631\u062a\u0641\u0627\u0639\u0627 \u0645\u0639\u0646\u0648\u064a\u0627\u064b \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 G1 \u0648 G2 (146.91\u00b11.93, (10.87\u00b10.3 \u0648 (11.15\u00b10.27, 148.5\u00b11.65) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a\u060c \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 G3 mg\/dl (6.97\u00b10.21, 105.51\u00b12.27)\u060c\u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/strong><\/p>\n

\u0644\u0645 \u062a\u0633\u062c\u0644 \u0646\u062a\u0627\u0626\u062c \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u0631\u0648\u0642\u064b\u0627 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(P\u22640.05) \u0641\u064a \u062c\u0645\u064a\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0644\u0642\u0648\u0646 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 3D \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u062a\u0644\u0642\u0648\u0646 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 (D3. \u0628\u0627\u0633\u062a\u062b\u0646\u0627\u0621 RANKL \u0627\u0644\u0630\u064a \u0633\u062c\u0644 \u0641\u0631\u0648\u0642\u0627\u064b \u0645\u0639\u0646\u0648\u064a\u0629.<\/strong><\/p>\n

\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0631\u0633\u0648\u0646 \u0644\u0640ANA \u00a0Anti-dsDNA PD-1, RANKL, \u00a0\u0648Sclerostin \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0627\u060c \u0645\u0627 \u0639\u062f\u0627 (ANA, anti-dsDNA) \u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a \u0627\u0631\u062a\u0628\u0627\u0637 \u0637\u0631\u062f\u064a \u0636\u0639\u064a\u0641 \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0645\u0627. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0638\u0647\u0631 Cu \u0648 Al \u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0643\u0633\u064a \u0645\u062a\u0648\u0633\u0637 \u0645\u0639 Zn \u0648\u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0643\u0633\u064a \u0636\u0639\u064a\u0641 \u0645\u0639 Ca\u060c \u0628\u064a\u0646\u0645\u0627 \u0623\u0638\u0647\u0631\u0627 Zn \u0648Ca \u0627\u0631\u062a\u0628\u0627\u0637 \u0637\u0631\u062f\u064a \u0645\u062a\u0648\u0633\u0637 \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0645\u0627.<\/strong><\/p>\n

\u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0623\u0646 PD-1 \u0648NFATc1 \u062a\u0639\u062a\u0628\u0631 \u0623\u0647\u062f\u0627\u0641\u0627\u064b \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u064a\u062f\u0629 \u0644\u062f\u0627\u0621 \u0627\u0644\u0630\u0626\u0628 \u0627\u0644\u0627\u062d\u0645\u0631\u0627\u0631\u064a \u0648\u0623\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a RANKL \u0648Sclerostin \u0641\u064a \u0627\u0644\u0645\u0635\u0644 \u0644\u0627 \u062a\u0639\u0643\u0633 \u0645\u0633\u062a\u0648\u064a\u0627\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u0639\u0638\u0627\u0645\u060c \u0648\u0623\u0646 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 Zn \u0648Cu \u0648Al \u0648Ca \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u062f\u0627\u0621 \u0627\u0644\u0630\u0626\u0628 \u0627\u0644\u0627\u062d\u0645\u0631\u0627\u0631\u064a.<\/strong><\/p>\n

\u0648\u062e\u0644\u0635\u062a \u0627\u0644\u0627\u0637\u0631\u0648\u062d\u0629 \u0627\u0644\u0649 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u0627\u062a\u064a\u0629 :<\/strong><\/p>\n

1- \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0645\u0635\u0644\u064a \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646\u0627\u062a \u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 C \u0648\u0641\u064a\u062a\u0627\u0645\u064a\u0646 K.<\/strong><\/p>\n

2- \u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a RANKL \u0648Sclerostin \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 RT-qPCR<\/strong><\/p>\n

3- \u062a\u0642\u062f\u064a\u0631\u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0629\u00a0 \u0644\u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0639\u0638\u0627\u0645 \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u00a0osteoprotegerin \u0648 Dickkopf 1.<\/strong><\/p>\n

4- \u062a\u0642\u064a\u064a\u0645 \u0643\u062b\u0627\u0641\u0629 \u0627\u0644\u0645\u0639\u0627\u062f\u0646 \u0641\u064a \u0627\u0644\u0639\u0638\u0627\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0637\u0627\u0642\u0629 (DXA).<\/strong><\/p>\n

5- \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u0646\u0632\u0631\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0627\u0644\u0643\u0627\u062f\u0645\u064a\u0648\u0645 \u0648\u0627\u0644\u0633\u064a\u0644\u064a\u0646\u064a\u0648\u0645 \u0648\u0627\u0644\u0645\u063a\u0646\u064a\u0633\u064a\u0648\u0645.<\/strong><\/p>\n

6- \u062a\u0642\u062f\u064a\u0631 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0643\u0648\u0644\u0627\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0645 \u0628\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0625\u0644\u064a\u0632\u0627.<\/strong><\/p>\n

7- \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u062c\u064a\u0646 TLR-7.<\/strong><\/p>\n

8- \u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u062c\u0646\u0633\u064a\u0629 \u0645\u062b\u0644 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646.<\/strong><\/p>\n

9- \u062f\u0631\u0627\u0633\u0629 \u0634\u062f\u0629 \u0648\u0646\u0634\u0627\u0637 \u0645\u0631\u0636 \u0627\u0644\u0630\u0626\u0628 \u0627\u0644\u0627\u062d\u0645\u0631\u0627\u0631\u064a.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

  \u0646\u0627\u0642\u0634 \u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0635\u0631\u0641\u0629 \u2013 \u0627\u0628\u0646 \u0627\u0644\u0647\u064a\u062b\u0645 \u060c \u0623\u0637\u0631\u0648\u062d\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 ” \u062a\u0642\u064a\u064a\u0645 \u0628\u0639\u0636….<\/i>\u0627\u0644\u0645\u0632\u064a\u062f<\/span><\/a><\/p>\n","protected":false},"author":25,"featured_media":53481,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[44,105,101,7,59,68,98,85,73,80,16],"tags":[23,61,48],"class_list":["post-53477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-44","category-3---","category-6----","category-7","category-59","category-68","category-98","category-85","category-73","category-bio-dept","category-16","tag-ihcoedu","tag-61","tag-bio"],"modified_by":"ihcoedu","_links":{"self":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/53477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53477"}],"version-history":[{"count":0,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/53477\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/53481"}],"wp:attachment":[{"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=53477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ihcoedu.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=53477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}